Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280486 | 0.86 | SMPD1 (0.53) | S1PR1 | |
| SCHEMBL19430786 | 0.81 | S1PR1 (0.47) | SPHK2S1PR1 | |
| SCHEMBL22280642 | 0.79 | S1PR1 (0.39) | SPHK2SPHK1S1PR1 | |
| SCHEMBL19430707 | 0.76 | SPHK2 (0.53) | SPHK2S1PR1 | |
| SCHEMBL19430878 | 0.74 | S1PR1 (0.50) | SPHK2S1PR1 | |
| SCHEMBL19430398 | 0.72 | S1PR1 (0.45) | SPHK2S1PR1 | |
| SCHEMBL17666209 | 0.72 | NPSR1 (0.39) | SPHK2S1PR1 | |
| SCHEMBL22280463 | 0.72 | SPHK2 (0.62) | SPHK2SPHK1S1PR1RXRARXRB | |
| SCHEMBL17666215 | 0.72 | SPHK2 (0.42) | SPHK2S1PR1 | |
| Hydrochloric Acid SCHEMBL29523175 | 0.72 | SPHK2 (0.62) | SPHK2SPHK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |