Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280466 | 0.79 | SPHK2 (0.49) | S1PR1SPHK2SPHK1 | |
| SCHEMBL22280486 | 0.72 | SMPD1 (0.53) | S1PR1HDAC6HDAC1 | |
| SCHEMBL19430707 | 0.71 | SPHK2 (0.53) | S1PR1SPHK2 | |
| SCHEMBL17666215 | 0.68 | SPHK2 (0.42) | S1PR1SPHK2 | |
| SCHEMBL22280483 | 0.67 | HDAC4 (0.47) | L3MBTL1HDAC4HDAC6HDAC1 | |
| SCHEMBL19430786 | 0.66 | S1PR1 (0.47) | S1PR1SPHK2 | |
| SCHEMBL19430602 | 0.66 | SPHK2 (0.46) | S1PR1SPHK2SPHK1BMP1 | |
| SCHEMBL20597746 | 0.66 | S1PR1 (0.71) | S1PR1 | |
| SCHEMBL22280481 | 0.66 | PPARD (0.47) | S1PR1ATMNPSR1L3MBTL1SPHK2 | |
| SCHEMBL22280272 | 0.66 | SPHK2 (0.39) | S1PR1NPSR1SPHK2SPHK1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |