Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242435 | 1.00 | TLR9 (0.55) | TLR9TLR8TLR7NPC1RAB9A | |
| SCHEMBL22280455 | 0.87 | TLR9 (0.50) | TLR9TLR8TLR7NPC1RAB9A | |
| SCHEMBL22280325 | 0.86 | RAB9A (0.71) | TLR9TLR8TLR7NPC1RAB9A | |
| SCHEMBL22280269 | 0.86 | RAB9A (0.71) | TLR9TLR8TLR7NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL193439 | 0.85 | RAB9A (0.69) | TLR9TLR8TLR7NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL193440 | 0.85 | RAB9A (0.69) | TLR9TLR8TLR7NPC1RAB9A | |
| SCHEMBL8241778 | 0.84 | CASP3 (0.73) | TLR9TLR8TLR7NPC1RAB9A | |
| SCHEMBL8241780 | 0.83 | TLR9 (0.63) | TLR9TLR8TLR7NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL193401 | 0.82 | NR1H4 (0.72) | TLR9TLR8TLR7NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL193402 | 0.82 | NR1H4 (0.72) | TLR9TLR8TLR7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |