Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 3/20 | 0.36 |
| ▸ | SDC2 | P34741 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.36 |
| ▸ | VHL | P40337 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284780 | 1.00 | SDCBP (0.36) | SDCBPSDC2MAPK1VHLNPC1 | |
| SCHEMBL2276572 | 0.91 | SMN1; SMN2 (0.41) | SDCBPSDC2MAPK1VHLNPC1 | |
| SCHEMBL13572379 | 0.91 | SDCBP (0.38) | SDCBPSDC2MAPK1VHLLMNA | |
| SCHEMBL2178926 | 0.89 | NPC1 (0.38) | SDCBPSDC2NPC1NFKB1RAB9A | |
| SCHEMBL2178932 | 0.89 | NPC1 (0.38) | SDCBPSDC2NPC1NFKB1RAB9A | |
| SCHEMBL2283333 | 0.88 | SDCBP (0.36) | SDCBPSDC2MAPK1VHLLMNA | |
| SCHEMBL2181260 | 0.85 | TRPV1 (0.42) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL13719176 | 0.85 | TRPV1 (0.42) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL2271028 | 0.83 | RARB (0.43) | SDCBPSDC2VHLLMNA | |
| SCHEMBL2178354 | 0.81 | GCK (0.38) | SDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |