Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20692058 | 1.00 | MEN1 (0.31) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL30042038 | 1.00 | MEN1 (0.31) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL6231710 | 0.80 | ACHE (0.42) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL23691685 | 0.79 | MAPT (0.33) | MAPT | |
| SCHEMBL21626228 | 0.79 | MEN1 (0.31) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL23674334 | 0.79 | MEN1 (0.31) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL23674373 | 0.79 | MEN1 (0.31) | MEN1ACHEMAPK1KMT2ABPTF | |
| SCHEMBL23691688 | 0.78 | NLRP3 (0.31) | MAPT | |
| SCHEMBL23674527 | 0.78 | NLRP3 (0.33) | — | |
| SCHEMBL25796524 | 0.78 | NLRP3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |