Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19791796 | 0.97 | ACHE (0.46) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL20681022 | 0.95 | ACHE (0.39) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL30498486 | 0.95 | ACHE (0.39) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL23808911 | 0.94 | ACHE (0.44) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL25404714 | 0.87 | ACHE (0.34) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL21810680 | 0.82 | ACHE (0.31) | ACHE | |
| SCHEMBL23674334 | 0.80 | MEN1 (0.31) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL22282173 | 0.80 | MEN1 (0.31) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL23674373 | 0.80 | MEN1 (0.31) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL20692058 | 0.80 | MEN1 (0.31) | ACHEMEN1KMT2AMAPK1BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 371 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150291-A1 | PROCESS FOR THE PREPARATION OF NLRP3 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2024-05-09 | — | — | US | claimed |
| EP-4359385-A2 | PROCESS FOR THE PREPARATION OF NLRP3 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-05-01 | — | — | EP | claimed |
| EP-3867231-B1 | NOVEL PROCESSES | INFLAZOME LTD (IE) | 2024-05-01 | — | — | EP | claimed |
| US-11724988-B2 | Processes | INFLAZOME LIMITED (IE) | 2023-08-15 | — | — | US | claimed |
| WO-2022268935-A2 | NOVEL PROCESS | F. HOFFMANN-LA ROCHE AG (CH) | 2022-12-29 | — | — | WO | claimed |
| US-20220064125-A1 | NOVEL PROCESSES | INFLAZOME LIMITED (IE) | 2022-03-03 | — | — | US | claimed |
| WO-2020079207-A1 | NOVEL PROCESSES | INFLAZOME LIMITED (IE) | 2020-04-23 | — | — | WO | claimed |
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | GENENTECH, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-20250388568-A1 | NLRP3 INHIBITORS | KODIAK SCIENCES INC (US) | 2025-12-25 | — | — | US | disclosed |
| US-12466800-B2 | N-((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)carbamoyl)-4, 5, 6, 7-tetrahydrobenzofuran-2-sulfonamide derivatives and related compounds as NLPR3 modulators for the treatment of multiple sclerosis (MS) | ZOMAGEN BIOSCIENCES LTD (US) | 2025-11-11 | — | — | US | disclosed |
| US-12459925-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2025-11-04 | — | — | US | disclosed |
| US-20250250294-A1 | COMPOUND, METAL COMPLEX, OLEFIN POLYMERIZATION CATALYST COMPOSITION, OLEFIN POLYMERIZATION CATALYST, AND METHOD FOR PRODUCING OLEFIN-BASED POLYMER | MITSUBISHI CHEMICAL CORPORATION (JP) | 2025-08-07 | — | — | US | disclosed |
| EP-4596562-A1 | COMPOUND, METAL COMPLEX, CATALYST COMPOSITION FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION AND METHOD FOR PRODUCING OLEFIN POLYMER | Mitsubishi Chemical Corporation (JP) | 2025-08-06 | — | — | EP | disclosed |
| EP-1270554-A1 | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1270565-A1 | 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-6461822-B2 | THERAPEUTIC TARGETS FOR AGENTS THAT SUPPRESS THE RELEASE OF INFLAMMATORY MEDIATORS SUCH AS INTERLEUKIN IL-1 AND IL-1 BETA | PFIZER INC. | 2002-10-08 | — | — | US | disclosed |
| US-6433009-B1 | TREATMENT OF AUTOIMMUNE, CARDIOVASCULAR, NERVOUS SYSTEM, GASTROINTESTINAL, RESPIRATORY SYSTEM, AND VIRAL DISORDERS; ANTIDIABETIC, ANTIARTHRITIC, ANTIINFLAMMATORY AND ANTIDEPRESSANT AGENTS | PFIZER INC | 2002-08-13 | — | — | US | disclosed |
| US-20020034764-A1 | DIARYLSULFONYLUREA BINDING PROTEINS | GABEL CHRISTOPHER A (US) | 2002-03-21 | — | — | US | disclosed |
| US-6166064-A | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity | PFIZER INC (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0987552-A2 | Diarylsulfonylurea binding proteins | Pfizer Products Inc. (US) | 2000-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150291-A1 | PROCESS FOR THE PREPARATION OF NLRP3 INHIBITORS | NLRP3, NOD1, NLRP1 | ACHE 4208/4885MEN1 4568/4885KMT2A 3839/4885 |
| US-20020034764-A1 | DIARYLSULFONYLUREA BINDING PROTEINS | HSPBP1, IL1B, IL1RN | ACHE 4872/4885MEN1 4366/4885KMT2A 4456/4885 |
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | NLRP3, NLRP1, PYCARD | ACHE 4848/4885MEN1 4299/4885KMT2A 3993/4885 |
| US-20250388568-A1 | NLRP3 INHIBITORS | NLRP3, NOD1, NLRP1 | ACHE 4794/4885MEN1 3586/4885KMT2A 4514/4885 |
| US-20220064125-A1 | NOVEL PROCESSES | NLRP3, NOD1, NLRP1 | ACHE 4519/4885MEN1 4329/4885KMT2A 4832/4885 |
| US-20250250294-A1 | COMPOUND, METAL COMPLEX, OLEFIN POLYMERIZATION CATALYST COMPOSITION, OLEFIN POLYMERIZATION CATALYST, AND METHOD FOR PRODUCING OLEFIN-BASED POLYMER | OSTC, PORCN, POF1B | ACHE 2585/4885MEN1 1397/4885KMT2A 1852/4885 |
| US-12466800-B2 | N-((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)carbamoyl)-4, 5, 6, 7-tetrahydrobenzofuran-2-sulfonamide derivatives and related compounds as NLPR3 modulators for the treatment of multiple sclerosis (MS) | FFAR3, NLRP3, NOD1 | ACHE 2420/4885MEN1 3405/4885KMT2A 4064/4885 |
| US-11724988-B2 | Processes | NLRP3, NOD1, NLRP1 | ACHE 3670/4885MEN1 3749/4885KMT2A 4604/4885 |
| US-12459925-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NLRP3, NOD1, IL1B | ACHE 4770/4885MEN1 2993/4885KMT2A 4062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.