Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922906 | 0.84 | MEN1 (0.52) | MAPTKDM4EGAAPOLBPPARG | |
| SCHEMBL657243 | 0.82 | KDM4E (0.64) | MAPTKDM4EHTTGAAPOLB | |
| Hydrochloric Acid SCHEMBL11536222 | 0.81 | MAPT (0.65) | MAPTKDM4EHTTGAAPOLB | |
| Ethyl Propionate SCHEMBL28309072 | 0.78 | F2 (0.50) | MAPTKDM4EGAAPOLBPPARG | |
| SCHEMBL19922886 | 0.78 | SMN1; SMN2 (0.47) | MAPTKDM4EGAAPOLBPPARG | |
| SCHEMBL17118308 | 0.77 | POLB (0.58) | MAPTKDM4EHTTPOLBCA12 | |
| SCHEMBL5411982 | 0.76 | POLB (0.62) | MAPTKDM4EHTTGAAPOLB | |
| SCHEMBL7103590 | 0.76 | CYP4F2 (0.64) | MAPTKDM4EHTTGAAPOLB | |
| SCHEMBL11119802 | 0.75 | AOC3 (0.47) | GAAPPARGPPARAMEN1KMT2A | |
| SCHEMBL7102017 | 0.74 | POLB (0.56) | MAPTKDM4EHTTPOLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510022-B1 | INDOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-05 | — | — | EP | disclosed |