SCHEMBL22282974

SCHEMBL22282974

COc1ncc(-c2ccccc2Br)c(C)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.38
CYP2C19 P33261 4/20 0.38
CYP3A4 P08684 3/20 0.38
PLK1 P53350 1/20 0.37
ALDH1A1 P00352 5/20 0.37
TSHR P16473 3/20 0.37
USP2 O75604 2/20 0.37
CYP2C9 P11712 2/20 0.37
HKDC1 Q2TB90 1/20 0.36
PADI1 Q9ULC6 1/20 0.36
PADI3 Q9ULW8 1/20 0.36
PADI4 Q9UM07 1/20 0.36
PADI2 Q9Y2J8 1/20 0.36
ATG4B Q9Y4P1 1/20 0.36
HSD17B10 Q99714 1/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CYP2D6 P10635 2/20 0.35
NSD2 O96028 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19813981 0.81 KMT2A (0.42) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL21224374 0.75 CYP1A2 (0.45) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL29421576 0.75 CYP1A2 (0.45) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL22282975 0.74 HSD11B1 (0.36) ALDH1A1TSHRHSD17B10SMN1; SMN2TP53
SCHEMBL22282976 0.72 EED (0.33) ALDH1A1KMT2AMEN1SMN1; SMN2TP53
SCHEMBL3564444 0.69 QPCT (0.45) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL13170685 0.68 NPC1 (0.51) ALDH1A1USP2HSD17B10KMT2AMEN1
SCHEMBL31082814 0.67 BACE1 (0.43) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL12051547 0.67 CYP1A2 (0.47) CYP1A2CYP2C19CYP3A4ALDH1A1TSHR
SCHEMBL4429261 0.65 CA1 (0.52) ALDH1A1TSHRHSD17B10KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3490985-B1 HERBICIDAL PYRIMIDINE COMPOUNDS BASF SE (DE) 2020-08-05 EP claimed