Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PLEC | Q15149 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18997033 | 0.82 | L3MBTL1 (0.56) | RIPK1L3MBTL1MAPTNPSR1SSTR4 | |
| SCHEMBL2881707 | 0.82 | RIPK1 (0.36) | RIPK1L3MBTL1MAPTNPSR1SSTR4 | |
| SCHEMBL13449767 | 0.81 | KDM4E (0.41) | RIPK1L3MBTL1MAPTNPSR1NUDT1 | |
| SCHEMBL14486495 | 0.81 | SLC6A2 (0.45) | L3MBTL1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL12251017 | 0.81 | RIPK1 (0.44) | RIPK1L3MBTL1MAPTNPSR1SSTR4 | |
| SCHEMBL13050344 | 0.78 | HRH1 (0.57) | L3MBTL1DRD2DRD1DRD3HTR1A | |
| SCHEMBL29819624 | 0.78 | L3MBTL1 (0.60) | L3MBTL1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL561755 | 0.78 | L3MBTL1 (0.60) | L3MBTL1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL2903189 | 0.76 | L3MBTL1 (0.58) | L3MBTL1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL2229365 | 0.76 | HTR7 (0.52) | L3MBTL1MAPTSSTR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090911-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| EP-1720836-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005082859-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-09 | — | — | WO | disclosed |