Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530107 | 0.89 | TSHR (0.63) | MEN1KMT2ATSHRHTTHPGD | |
| SCHEMBL18646228 | 0.86 | HPGD (0.55) | TSHRHTTPTGDR2HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27594379 | 0.86 | NAAA (0.62) | MEN1KMT2ATSHRHTTHPGD | |
| SCHEMBL461599 | 0.86 | HPGD (0.64) | MEN1KMT2ATSHRHTTP2RX7 | |
| SCHEMBL31686014 | 0.86 | HPGD (0.64) | MEN1KMT2ATSHRHTTP2RX7 | |
| SCHEMBL4155532 | 0.86 | KMT2A (0.50) | MEN1KMT2ATSHRHTTP2RX7 | |
| SCHEMBL13614178 | 0.85 | NAAA (0.56) | MEN1KMT2ATSHRHTTHPGD | |
| SCHEMBL27404315 | 0.84 | POLB (0.53) | KMT2ATSHRHTTHPGDL3MBTL1 | |
| SCHEMBL7105503 | 0.83 | TSHR (0.51) | MEN1KMT2ATSHRHTTPTGDR2 | |
| SCHEMBL5123028 | 0.83 | TSHR (0.51) | KMT2ATSHRHTTPTGDR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | claimed |
| US-8735384-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-05-27 | — | — | US | disclosed |
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | AMGEN INC. (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011090911-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| EP-1846407-A1 | 7-{4-[2-(2,6-DICHLORO-4-METHYLPHENOXY)ETHOXY]PHENYL}-3,9-DIAZABICYCLO[3.3.31]NON-6-ENE-6-CARBOXYLIC ACID CYCLOPROPYL-(2,3-DIMETHYLBENZYL)AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION. | Actelion Pharmaceuticals Ltd. (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006079988-A1 | 7- {4- [2- (2 , 6-DICHL0R0-4-METHYLPHEN0XY) ETHOXY] PHENYL}-3 , 9-DIAZABICYCLO [3 .3 . 31] NON - 6-ENE- S- CARBOXYLIC ACID CYCLOPROPYL- (2 , 3-DIMETHYLBENZYD AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | BACE1, BACE2, APH1B | MEN1 4321/4885KMT2A 1229/4885TSHR 3909/4885 |
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | MEN1 4622/4885KMT2A 2013/4885TSHR 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.