SCHEMBL13614178

SCHEMBL13614178

CCCNC(=O)c1cccc(O)c1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.56
ALOX5 P09917 1/20 0.54
TSHR P16473 2/20 0.53
HTT P42858 2/20 0.53
L3MBTL1 Q9Y468 3/20 0.48
POLB P06746 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HPGD P15428 2/20 0.46
THRB P10828 1/20 0.46
RECQL P46063 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 2/20 0.46
GAA P10253 1/20 0.46
NPC1 O15118 1/20 0.45
MAPT P10636 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HSD17B10 Q99714 1/20 0.45
NLRP1 Q9C000 1/20 0.45
ADRA1D P25100 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12677093 0.86 CA1 (0.50) NAAAALOX5TSHRHTTL3MBTL1
SCHEMBL2228385 0.85 MEN1 (0.54) TSHRHTTL3MBTL1POLBMEN1
SCHEMBL1238119 0.84 NAAA (0.76) NAAAALOX5TSHRHTTL3MBTL1
SCHEMBL5123028 0.82 TSHR (0.51) NAAATSHRHTTL3MBTL1POLB
SCHEMBL18646228 0.81 HPGD (0.55) NAAAALOX5TSHRHTTL3MBTL1
SCHEMBL5727441 0.80 HPGD (0.55) TSHRHTTPOLBKMT2AHPGD
SCHEMBL2467646 0.79 P2RX7 (0.56) ALOX5TSHRHTTMEN1KMT2A
SCHEMBL14469883 0.79 L3MBTL1 (0.53) NAAAALOX5TSHRHTTL3MBTL1
SCHEMBL24072468 0.78 HTT (0.54) NAAAALOX5TSHRHTTL3MBTL1
SCHEMBL14205917 0.78 TSHR (0.54) NAAAALOX5TSHRHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1432700-B1 SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS BRISTOL MYERS SQUIBB CO (US) 2009-11-04 EP disclosed