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SCHEMBL22285173

SCHEMBL22285173

CC(C)(C)OC(=O)N1CCNC[C@@H]1c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 7/20 0.49
▸ NR1H3 Q13133 6/20 0.49
▸ RIPK1 Q13546 3/20 0.46
▸ RXRA P19793 2/20 0.43
▸ GPR119 Q8TDV5 1/20 0.42
▸ PARP1 P09874 1/20 0.42
▸ MAPK1 P28482 1/20 0.41
▸ RORC P51449 1/20 0.40
▸ DPP4 P27487 1/20 0.40
▸ DPP7 Q9UHL4 1/20 0.40
▸ ABCB1 P08183 1/20 0.40
▸ ROCK2 O75116 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4325057 1.00 NR1H2 (0.49) NR1H2NR1H3RIPK1RXRAGPR119
SCHEMBL874416 1.00 NR1H2 (0.49) NR1H2NR1H3RIPK1RXRAGPR119
SCHEMBL25913721 0.88 DPP4 (0.47) NR1H2NR1H3PARP1RORCDPP4
SCHEMBL3697218 0.88 DPP4 (0.47) NR1H2NR1H3PARP1RORCDPP4
SCHEMBL6267046 0.88 RIPK1 (0.51) NR1H2NR1H3RIPK1RXRAGPR119
SCHEMBL26115692 0.87 PARP1 (0.43) NR1H2NR1H3RIPK1GPR119PARP1
SCHEMBL28304239 0.87 NR1H2 (0.50) NR1H2NR1H3PARP1RORCDPP4
SCHEMBL1673503 0.87 MEN1 (0.43) NR1H2NR1H3RIPK1PARP1
SCHEMBL8140446 0.87 PARP1 (0.43) NR1H2NR1H3PARP1MAPK1DPP4
SCHEMBL30595864 0.87 RIPK1 (0.53) NR1H2NR1H3RIPK1RXRAGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4674484-A2 THIENOPYRROLE COMPOUNDS Gilead Sciences, Inc. (US) 2026-01-07 — — EP disclosed
EP-4291562-B1 THIENOPYRROLE COMPOUNDS GILEAD SCIENCES INC (US) 2025-09-10 — — EP disclosed
US-12234225-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2025-02-25 — — US disclosed
CN-113874080-B IL-17A modulators and uses thereof 戴斯阿尔法公司 2024-09-27 — — CN disclosed
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF DICE MOLECULES SV, INC. 2023-02-23 — — US disclosed
US-11447468-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2022-09-20 — — US disclosed
CN-113874080-A IL-17A modulators and uses thereof 戴斯阿尔法公司 2021-12-31 — — CN disclosed
EP-3921038-A1 IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2021-12-15 — — EP disclosed
WO-2020163554-A1 IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2020-08-13 — — WO disclosed
US-20200247785-A1 IL-17 Ligands And Uses Thereof DICE MOLECULES SV, INC. 2020-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF IL17A, IL2, IL15 NR1H2 441/4885NR1H3 517/4885RIPK1 645/4885
US-11447468-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 NR1H2 441/4885NR1H3 517/4885RIPK1 645/4885
US-20200247785-A1 IL-17 Ligands And Uses Thereof IL17A, IL2, IL15 NR1H2 441/4885NR1H3 517/4885RIPK1 645/4885
US-12234225-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 NR1H2 441/4885NR1H3 517/4885RIPK1 645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.