SCHEMBL22288142

SCHEMBL22288142

FC(F)(F)Sc1cccc2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.40
HSD17B10 Q99714 5/20 0.40
CYP2A6 P11509 3/20 0.40
TSHR P16473 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
IFNAR1 P17181 1/20 0.40
LMNA P02545 1/20 0.39
NPY1R P25929 1/20 0.39
MAPK1 P28482 1/20 0.39
NPY2R P49146 1/20 0.39
CYP1A2 P05177 5/20 0.38
HPGD P15428 4/20 0.38
CYP3A4 P08684 1/20 0.38
KEAP1 Q14145 1/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
HPRT1 P00492 1/20 0.37
PKM P14618 1/20 0.36
HTT P42858 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22288291 0.88 HPRT1 (0.52) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL10842543 0.82 AKR1B1 (0.38) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL28439024 0.82 ALDH1A1 (0.38) ALDH1A1HSD17B10CYP1A2HPGDPKM
SCHEMBL21504652 0.78 IFNAR1 (0.43) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL9018805 0.78 CYP1A2 (0.43) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL31435109 0.77 HSD17B1 (0.42) CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL11215955 0.77 ALDH1A1 (0.39) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL17288951 0.76 CCR2 (0.31) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL28890095 0.75 HSD17B10 (0.47) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL31167972 0.74 IFNAR1 (0.60) ALDH1A1HSD17B10CYP2A6TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114835646-B Imidazole trifluoro methylthio reagent and synthesis application thereof 清华大学 2024-01-30 CN disclosed
CN-111801329-A Heteroaryl pyrimidine compound and pest control agent 日本曹达株式会社 2020-10-20 CN disclosed
WO-2020155595-A1 AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR 清华大学 2020-08-06 WO disclosed
CN-106659161-B Amide compound and its harmful arthropod prevent and kill off purposes 住友化学株式会社 2019-08-02 CN disclosed