Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558668 | 0.91 | TSHR (0.50) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL9182805 | 0.86 | KDM4E (0.39) | LMNASLC22A6TSHRPMP22ALOX5 | |
| SCHEMBL25660621 | 0.86 | LMNA (0.38) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL27953679 | 0.79 | KDM5A (0.44) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL4612433 | 0.78 | — | — | |
| SCHEMBL29193847 | 0.78 | KDM5A (0.53) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL11580408 | 0.77 | LMNA (0.35) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL22303813 | 0.77 | — | — | |
| SCHEMBL4361532 | 0.74 | KDM5A (0.51) | LMNASLC22A6TSHRPMP22NFKB1 | |
| SCHEMBL4352140 | 0.74 | KDM5A (0.56) | LMNASLC22A6TSHRPMP22NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113348164-B | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-111517939-B | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-113348164-A | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-111517939-A | Preparation method and intermediate of fused tricyclic derivative | 四川海思科制药有限公司 | 2020-08-11 | — | — | CN | disclosed |
| WO-2020155952-A1 | PREPARATION METHOD FOR FUSED TRICYCLIC DERIVATIVE AND INTERMEDIATE | 四川海思科制药有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2020155952-A1 | PREPARATION METHOD FOR FUSED TRICYCLIC DERIVATIVE AND INTERMEDIATE | 四川海思科制药有限公司 | 2020-08-06 | — | — | WO | disclosed |