Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 2/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.44 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31577324 | 1.00 | SHMT2 (0.50) | SHMT2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL11935975 | 0.90 | SHMT2 (0.57) | SHMT2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL13054791 | 0.86 | SMN1; SMN2 (0.46) | LMNAMAPTSMN1; SMN2TDP1MAPK1 | |
| SCHEMBL24969073 | 0.82 | TAAR1 (0.50) | SHMT2TAAR1RPS6KB1APPHDAC4 | |
| SCHEMBL30152251 | 0.82 | TAAR1 (0.50) | SHMT2TAAR1RPS6KB1APPHDAC4 | |
| SCHEMBL11935988 | 0.77 | MAPT (0.63) | SHMT2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL9337417 | 0.76 | SHMT2 (0.57) | SHMT2MEN1LMNAPOLBMAPT | |
| SCHEMBL16625699 | 0.76 | KCNQ3 (0.47) | SHMT2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL11935875 | 0.75 | HDAC1 (0.48) | MEN1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL5203429 | 0.75 | SHMT2 (0.56) | SHMT2LMNAPOLBSMN1; SMN2KCNH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917907-A1 | MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF | Universitá Degli Studi Di Salerno (IT) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020157126-A1 | MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF | Università degli Studi di Salerno (IT) | 2020-08-06 | — | — | WO | disclosed |