SCHEMBL16625699

SCHEMBL16625699

Cc1cc(F)c(NCc2ccc(F)cc2)cc1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 3/20 0.47
KCNQ2 O43526 3/20 0.47
KCNQ4 P56696 1/20 0.47
KCNQ5 Q9NR82 1/20 0.47
MEN1 O00255 5/20 0.45
KMT2A Q03164 5/20 0.45
POLB P06746 3/20 0.45
LMNA P02545 2/20 0.45
MAPT P10636 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
SHMT2 P34897 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HTT P42858 1/20 0.40
ATM Q13315 1/20 0.40
GPR35 Q9HC97 1/20 0.40
ALDH1A1 P00352 1/20 0.40
ABCB11 O95342 1/20 0.39
ESR1 P03372 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15347837 0.79 KCNQ3 (0.54) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL15348372 0.77 MAPT (0.50) MEN1KMT2APOLBLMNAMAPT
SCHEMBL16625703 0.76 KCNQ3 (0.57) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL13829230 0.76 KCNQ3 (0.54) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL22288489 0.76 SHMT2 (0.50) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL31577324 0.76 SHMT2 (0.50) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL15357203 0.76 KCNQ2 (0.76) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL16625700 0.75 KCNQ3 (0.53) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL16625701 0.74 KCNQ3 (0.46) KCNQ3KCNQ2KCNQ4KCNQ5MEN1
SCHEMBL15526708 0.74 KCNQ3 (0.46) KCNQ3KCNQ2KCNQ4KCNQ5POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9556114-B2 Fluorinated 2-amino-4-(benzylamino)phenylcarbamate derivatives SCIFLUOR LIFE SCIENCES, INC. (US) 2017-01-31 US disclosed
US-20150098902-A1 Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives SCIFLUOR LIFE SCIENCES, INC. 2015-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150098902-A1 Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives FAAH, CACNA1B, FAAH2 KCNQ3 48/4885KCNQ2 30/4885KCNQ4 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.