Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912695 | 0.87 | TRPM8 (0.68) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL1912694 | 0.81 | TRPM8 (0.73) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL1912702 | 0.78 | TRPM8 (0.61) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL20616667 | 0.76 | TRPM8 (0.59) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL29964837 | 0.75 | TRPM8 (0.71) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL8576957 | 0.74 | DRD2 (0.67) | TRPM8DRD2HTR2ASIGMAR1ADRA1D | |
| SCHEMBL30724364 | 0.74 | TRPM8 (0.66) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL3703772 | 0.73 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3708561 | 0.73 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3704595 | 0.72 | NAMPT (0.82) | NAMPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677334-B | Transient receptor potential MELASTATIN 8 (TRPM 8) antagonists and related methods | 马歇尔大学科研协会 | 2024-04-09 | — | — | CN | disclosed |
| EP-3917510-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | Marshall University Research Corporation (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113677334-A | Transient receptor potential MELASTATIN 8(TRPM8) antagonists and related methods | 马歇尔大学科研协会 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020160464-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |