Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912695 | 0.82 | TRPM8 (0.68) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL1912694 | 0.78 | TRPM8 (0.73) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL22289581 | 0.78 | TRPM8 (0.61) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL29964837 | 0.75 | TRPM8 (0.71) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL30724364 | 0.74 | TRPM8 (0.66) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL20616667 | 0.74 | TRPM8 (0.59) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL12481142 | 0.71 | TRPM8 (0.59) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL2345904 | 0.71 | EPHX2 (0.67) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL23957140 | 0.71 | TRPM8 (0.53) | TRPM8EPHX2EPHX1DRD2HTR2A | |
| SCHEMBL23957152 | 0.70 | CHRNA7 (0.66) | TRPM8EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010135-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | XENON PHARMACEUTICALS INC. (CA) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010135-A1 | SPIRO DERIVATIVES FOR THE MODULATION OF STEAROYL-COA DESATURASE | SCD, SCD5, FADS2 | TRPM8 1824/4885EPHX2 1662/4885EPHX1 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.