Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | PPIB | P23284 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22289634 | 0.83 | KMT2A (0.47) | KMT2APPIBALDH1A1 | |
| SCHEMBL22312050 | 0.81 | KMT2A (0.48) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22289651 | 0.80 | FOLH1 (0.46) | KMT2APPIB | |
| SCHEMBL6170106 | 0.79 | KMT2A (0.54) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22312043 | 0.78 | KMT2A (0.52) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22289627 | 0.77 | PPIB (0.61) | KMT2APPIBPDK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29472307 | 0.76 | KMT2A (0.51) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1115030 | 0.75 | PGR (0.54) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20941576 | 0.75 | ALDH1A1 (0.51) | KMT2ARORCALDH1A1 | |
| SCHEMBL1114974 | 0.75 | PGR (0.54) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917627-A1 | ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160134-A1 | ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |