Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 5/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765854 | 0.84 | KMT2A (0.43) | KMT2ARAB9AMLYCDALDH1A1MAPT | |
| SCHEMBL22312043 | 0.84 | KMT2A (0.52) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL29472307 | 0.83 | KMT2A (0.51) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL21776422 | 0.80 | KMT2A (0.46) | KMT2ARORCITKGSK3BALDH1A1 | |
| SCHEMBL7873808 | 0.79 | PGR (0.61) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22289643 | 0.79 | KMT2A (0.54) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5317092 | 0.78 | CHRNB2 (0.49) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9956677 | 0.78 | PGR (0.49) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1114974 | 0.78 | PGR (0.54) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1821084 | 0.78 | KMT2A (0.60) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556361-A2 | 2-ALKYL-(2-AMINO-3-ARYL-PROPIONYL)-PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY | THE PROCTER & GAMBLE COMPANY (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004037797-A2 | 2 - ALKYL - (2 - AMINO - 3 - ARYL - PROPIONYL) - PIPERAZINE DERIVATIVES AND RELATED COMPOUNDS AS MELANOCORTIN RECEPTOR LIGANDS FOR THE TREATMENT OF OBESITY | THE PROCTER & GAMBLE COMPANY (US) | 2004-05-06 | — | — | WO | claimed |