Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | MFN2 | O95140 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22289848 | 1.00 | EPHX2 (0.54) | EPHX2EPHX1MFN2RAB9ASIGMAR1 | |
| SCHEMBL4022912 | 0.86 | EPHX2 (0.62) | EPHX2EPHX1MFN2SIGMAR1HPGD | |
| SCHEMBL6700011 | 0.86 | EPHX2 (0.62) | EPHX2EPHX1MFN2SIGMAR1HPGD | |
| SCHEMBL30645033 | 0.82 | EPHX1 (0.77) | EPHX2EPHX1MFN2RAB9ATSHR | |
| SCHEMBL22300648 | 0.82 | MFN2 (0.56) | EPHX2EPHX1MFN2RAB9ASIGMAR1 | |
| SCHEMBL22301073 | 0.82 | RAB9A (0.57) | EPHX2EPHX1MFN2RAB9AHPGD | |
| SCHEMBL22289564 | 0.81 | EPHX1 (0.75) | EPHX2EPHX1MFN2RAB9A | |
| SCHEMBL22289572 | 0.81 | EPHX1 (0.75) | EPHX2EPHX1MFN2RAB9A | |
| SCHEMBL22289565 | 0.81 | EPHX1 (0.75) | EPHX2EPHX1MFN2RAB9A | |
| SCHEMBL4180735 | 0.80 | EPHX2 (0.69) | EPHX2EPHX1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917509-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | Mitochondria Emotion, Inc. (US) | 2021-12-08 | — | — | EP | claimed |
| WO-2020159797-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-08-06 | — | — | WO | claimed |
| US-20210251925-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2021-08-19 | — | — | US | disclosed |
| US-11083699-B2 | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof | MITOCHONDRIA EMOTION, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| WO-2020159797-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MITOCHONDRIA EMOTION, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200345668-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | EPHX2 3873/4885EPHX1 3536/4885MFN2 1/4885 |
| US-11083699-B2 | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof | MFN2, TFB2M, HADHA | EPHX2 3873/4885EPHX1 3536/4885MFN2 1/4885 |
| US-20210251925-A1 | TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF | MFN2, TFB2M, HADHA | EPHX2 3873/4885EPHX1 3536/4885MFN2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.