Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290217 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2C19CASP3ALDH1A1MEN1 | |
| SCHEMBL22290264 | 0.76 | CASP3 (0.48) | CYP1A2CYP2C19CASP3ALDH1A1MEN1 | |
| SCHEMBL4424799 | 0.74 | CASP3 (0.79) | CYP1A2CYP2C19CASP3ALDH1A1RPS6KA2 | |
| SCHEMBL22309089 | 0.74 | CASP3 (0.49) | CYP1A2CYP2C19CASP3ALDH1A1MEN1 | |
| SCHEMBL26963703 | 0.73 | ALDH1A1 (0.54) | CASP3ALDH1A1MEN1PKMKMT2A | |
| SCHEMBL29940891 | 0.73 | ALDH1A1 (0.54) | CASP3ALDH1A1MEN1PKMKMT2A | |
| SCHEMBL399990 | 0.73 | ALDH1A1 (0.54) | CYP1A2CYP2C19CASP3ALDH1A1MEN1 | |
| SCHEMBL2644044 | 0.72 | CASP3 (0.87) | CYP1A2CYP2C19CASP3ALDH1A1NPC1 | |
| SCHEMBL4417314 | 0.71 | CASP3 (0.59) | CYP1A2CYP2C19CASP3ALDH1A1NPC1 | |
| SCHEMBL1777850 | 0.71 | KDM4E (0.55) | CYP1A2CYP2C19CASP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| EP-3917919-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLH, POLB | CYP1A2 931/4885CYP2C19 938/4885CASP3 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.