SCHEMBL22290251

SCHEMBL22290251

CC(=O)Oc1ccc(CC(N)C(=O)NC(Cc2ccc(OC(C)=O)c(OC(C)=O)c2)C(=O)O)cc1OC(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
ALOX15 P16050 5/20 0.43
MME P08473 5/20 0.42
ACE P12821 4/20 0.42
CPA1 P15085 4/20 0.42
ACE2 Q9BYF1 4/20 0.42
FPR2 P25090 1/20 0.42
LDHA P00338 1/20 0.42
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1071712 1.00 HDAC3 (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1070143 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL1070175 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL25265326 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL1070178 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL25192552 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL1070147 0.95 FPR2 (0.49) ALOX15MMEACECPA1ACE2
SCHEMBL25471841 0.93 ALOX15 (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1070082 0.92 ACE (0.46) ALOX15MMEACECPA1ACE2
SCHEMBL25471845 0.91 HDAC3 (0.48) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3917504-A1 COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION Arizona Board of Regents on behalf of the University of Arizona (US) 2021-12-08 EP disclosed
WO-2020160256-A1 COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2020-08-06 WO disclosed