SCHEMBL25192552

SCHEMBL25192552

CC(=O)Oc1ccc(C[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)O)cc1OC(C)=O

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 1/20 0.49
MME P08473 4/20 0.48
ALDH1A1 P00352 1/20 0.47
ALOX15 P16050 1/20 0.47
ACE P12821 3/20 0.47
CPA1 P15085 3/20 0.47
ACE2 Q9BYF1 3/20 0.47
OPRD1 P41143 5/20 0.47
OPRM1 P35372 4/20 0.47
OPRK1 P41145 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1070175 1.00 FPR2 (0.49) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL1070143 1.00 FPR2 (0.49) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL1070178 1.00 FPR2 (0.49) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL25265326 1.00 FPR2 (0.49) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL1070147 1.00 FPR2 (0.49) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL22290251 0.95 HDAC3 (0.44) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL1071712 0.95 HDAC3 (0.44) FPR2MMEALDH1A1ALOX15ACE
SCHEMBL1070478 0.91 OPRK1 (0.58) ALDH1A1OPRK1
SCHEMBL1069413 0.91 OPRK1 (0.58) ALDH1A1OPRK1
SCHEMBL1067140 0.89 TACR1 (0.51) MMEALDH1A1ACEOPRD1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240207410-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF NEURODERM, LTD. (IL) 2024-06-27 US claimed
EP-4305049-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF Neuroderm Ltd (IL) 2024-01-17 EP claimed
CN-116964069-A Stabilized liquid compositions comprising levodopa-tyrosine conjugates and uses thereof 纽罗德姆有限公司 2023-10-27 CN claimed
WO-2022190100-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF NEURODERM, LTD. (IL) 2022-09-15 WO claimed
US-20250082595-A1 METHODS AND COMPOSITIONS FOR TREATING PARKINSON’S DISEASE NEURODERM LTD (IL) 2025-03-13 US disclosed
EP-4460289-A1 METHODS AND COMPOSITIONS FOR TREATING PARKINSON'S DISEASE Neuroderm, Ltd. (IL) 2024-11-13 EP disclosed
CN-118765198-A Methods and compositions for treating parkinson's disease 纽罗德姆有限公司 2024-10-11 CN disclosed
US-20240315997-A1 METHOD OF TREATMENT OF PARKINSON’S DISEASE NEURODERM, LTD. (IL) 2024-09-26 US disclosed
US-20240207410-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF NEURODERM, LTD. (IL) 2024-06-27 US disclosed
EP-4305049-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF Neuroderm Ltd (IL) 2024-01-17 EP disclosed
US-11844754-B2 Methods for treatment of Parkinson's disease NEURODERM, LTD. (IL) 2023-12-19 US disclosed
CN-116964069-A Stabilized liquid compositions comprising levodopa-tyrosine conjugates and uses thereof 纽罗德姆有限公司 2023-10-27 CN disclosed
WO-2023126945-A1 METHODS AND COMPOSITIONS FOR TREATING PARKINSON'S DISEASE NEURODERM, LTD. (IL) 2023-07-06 WO disclosed
US-20230157985-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEURODERM, LTD. (IL) 2023-05-25 US disclosed
WO-2022190100-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF NEURODERM, LTD. (IL) 2022-09-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11844754-B2 Methods for treatment of Parkinson's disease DDC, DDT, SLC6A3 FPR2 3945/4885MME 218/4885ALDH1A1 609/4885
US-20240207410-A1 STABILIZED LIQUID COMPOSITIONS COMPRISING A LEVODOPA-TYROSINE CONJUGATE AND USES THEREOF COMT, TH, DDT FPR2 3927/4885MME 1412/4885ALDH1A1 398/4885
US-20240315997-A1 METHOD OF TREATMENT OF PARKINSON’S DISEASE DDC, DDT, COMT FPR2 3903/4885MME 212/4885ALDH1A1 647/4885
US-20250082595-A1 METHODS AND COMPOSITIONS FOR TREATING PARKINSON’S DISEASE DDC, COMT, DDT FPR2 4047/4885MME 344/4885ALDH1A1 547/4885
US-20230157985-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE DDC, DDT, COMT FPR2 3895/4885MME 203/4885ALDH1A1 590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.