Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400107 | 0.86 | RAB9A (0.47) | RAB9AHDAC2JAK2JAK1MEN1 | |
| SCHEMBL21417415 | 0.86 | RAB9A (0.42) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL793727 | 0.84 | RAB9A (0.51) | RAB9AHDAC2JAK2JAK1TSHR | |
| SCHEMBL5568829 | 0.84 | RAB9A (0.43) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL1692767 | 0.83 | RAB9A (0.45) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL14243062 | 0.83 | CHRNB2 (0.54) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL793658 | 0.82 | RAB9A (0.49) | RAB9AJAK2JAK1MEN1KMT2A | |
| SCHEMBL19308678 | 0.81 | HDAC2 (0.44) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL20002117 | 0.80 | RAB9A (0.43) | RAB9AHDAC2CHRNB2CHRNA4JAK2 | |
| SCHEMBL15703162 | 0.80 | RAB9A (0.43) | RAB9AHDAC2CHRNB2CHRNA4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |