Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20813395 | 0.81 | KIT (0.50) | ENPP1AURKAEGFR | |
| SCHEMBL31400270 | 0.81 | KIT (0.50) | ENPP1AURKAEGFR | |
| SCHEMBL22300383 | 0.81 | EGFR (0.53) | ENPP1PDE5AAURKARPS6KB1EGFR | |
| SCHEMBL24009039 | 0.78 | HTR1A (0.36) | ENPP1TRPA1HTR1AADRA1DADRA1A | |
| SCHEMBL19390600 | 0.77 | HTR1A (0.42) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL17178224 | 0.76 | TNKS (0.50) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL24009016 | 0.75 | CDK2 (0.42) | ENPP1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13313198 | 0.75 | ADORA2A (0.51) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL25841384 | 0.72 | FDPS (0.41) | ENPP1FDPSBTK | |
| SCHEMBL17174414 | 0.70 | TNKS (0.40) | ENPP1HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-02-20 | — | — | US | disclosed |
| CN-113677350-B | ENPP1 inhibitors and methods of modulating immune responses | 里兰斯坦福初级大学理事会 | 2025-01-14 | — | — | CN | disclosed |
| US-20220289775-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-15 | — | — | US | disclosed |
| EP-3917536-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | The Board of Trustees of the Leland Stanford Junior University (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113677350-A | ENPP1 inhibitors and methods of modulating immune responses | 里兰斯坦福初级大学理事会 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020160333-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160333-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289775-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | ENPP1, STING1, ENPP2 | ENPP1 1/4885TRPA1 4790/4885FDPS 2831/4885 |
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | ENPP1, STING1, ENPP2 | ENPP1 1/4885TRPA1 4790/4885FDPS 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.