Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.42 |
| ▸ | CASP5 | P51878 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229278 | 1.00 | SYK (0.45) | SYKCTSLABCB1P2RX7CASP1 | |
| SCHEMBL1931615 | 0.85 | ABCB1 (0.46) | SYKCTSLABCB1P2RX7CASP1 | |
| SCHEMBL2228500 | 0.85 | ABCB1 (0.43) | SYKCTSLABCB1P2RX7CASP1 | |
| SCHEMBL2228512 | 0.83 | PDK1 (0.51) | SYKCTSLP2RX7 | |
| SCHEMBL2228519 | 0.83 | PDK1 (0.51) | SYKCTSLP2RX7 | |
| SCHEMBL2228517 | 0.83 | PDK1 (0.51) | SYKCTSLP2RX7 | |
| SCHEMBL13017316 | 0.79 | P2RX7 (0.46) | CTSLABCB1P2RX7CASP1CASP3 | |
| SCHEMBL9611357 | 0.79 | P2RX7 (0.46) | CTSLABCB1P2RX7CASP1CASP3 | |
| SCHEMBL2731742 | 0.79 | P2RX7 (0.46) | CTSLABCB1P2RX7CASP1CASP3 | |
| SCHEMBL12237104 | 0.78 | CTSL (0.47) | SYKCTSLCASP1CASP3CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |