Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28662062 | 0.86 | ADRB2 (0.45) | ADRB2MAOAMAOBALDH1A1CYP19A1 | |
| SCHEMBL1067198 | 0.86 | PLA2G10 (0.50) | ADRB2MAOAMAOBNOS3NOS1 | |
| SCHEMBL20041146 | 0.83 | NOS1 (0.47) | ALDH1A1NOS3NOS1NOS2SLC7A5 | |
| SCHEMBL23643229 | 0.83 | NOS1 (0.47) | ALDH1A1NOS3NOS1NOS2SLC7A5 | |
| SCHEMBL28133621 | 0.83 | ADRB2 (0.45) | ADRB2MAOAMAOBALDH1A1CYP19A1 | |
| SCHEMBL18500970 | 0.82 | SLC7A5 (0.42) | NOS3NOS1NOS2SLC7A5 | |
| SCHEMBL28497180 | 0.82 | SLC7A5 (0.47) | ADRB2ALDH1A1DDX3XSLC7A5 | |
| SCHEMBL28497181 | 0.82 | SLC7A5 (0.47) | ADRB2ALDH1A1DDX3XSLC7A5 | |
| SCHEMBL27744395 | 0.81 | SMN1; SMN2 (0.43) | ADRB2MAOAALDH1A1 | |
| SCHEMBL24899382 | 0.81 | MAOB (0.45) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55162770-A | — | — | None | — | — | JP | disclosed |
| EP-2519235-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-2361248-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2011-08-31 | — | — | EP | disclosed |
| WO-2011090760-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2009158571-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS AND USES THEREOF (US) | 2009-12-30 | — | — | WO | disclosed |
| JP-S55162770-A | IMPROVED PREPARATION OF 2,3,3-TRIMETHYL-INDOLENINE | CHISSO CORP | 1980-12-18 | — | — | JP | disclosed |