Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21236025 | 0.90 | PDGFRA (0.46) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL14966816 | 0.87 | PDGFRB (0.59) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL22295398 | 0.84 | FGFR2 (0.44) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL14540562 | 0.83 | SRC (0.47) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL19957325 | 0.82 | ALDH1A1 (0.52) | PDGFRBPDGFRASRCTGFBR1FGFR2 | |
| SCHEMBL22295341 | 0.81 | PDGFRB (0.58) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL15536773 | 0.78 | MET (0.48) | PDGFRBPDGFRAKDRFGFR2 | |
| SCHEMBL25719085 | 0.77 | AXL (0.49) | PDGFRBPDGFRAKDRFGFR2 | |
| SCHEMBL19957437 | 0.76 | PDGFRA (0.43) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL3894594 | 0.75 | SRC (0.65) | PDGFRBPDGFRASRCTGFBR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689351-A1 | QUINOLINE DERIVATIVE AND APPLICATION THEREOF AS TYROSINE KINASE INHIBITOR | Medshine Discovery Inc. (CN) | 2020-08-05 | — | — | EP | disclosed |