Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881971 | 1.00 | HTR2B (0.41) | HTR2BHIF1ADGAT1USP30CHRNA7 | |
| SCHEMBL2227305 | 0.70 | DGAT1 (0.35) | HTR2BDGAT1USP30CHRNA7KCNH2 | |
| SCHEMBL2554720 | 0.65 | HIF1A (0.56) | HIF1AUSP30MEN1KMT2ATDP1 | |
| SCHEMBL6264166 | 0.65 | MAPT (0.53) | HIF1AUSP30MEN1KMT2ATDP1 | |
| SCHEMBL71034 | 0.65 | HIF1A (0.55) | HIF1A | |
| SCHEMBL29929320 | 0.65 | HIF1A (0.55) | HIF1A | |
| SCHEMBL24198723 | 0.64 | HIF1A (0.49) | HIF1ADGAT1MEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL28470042 | 0.63 | HIF1A (0.54) | HIF1A | |
| SCHEMBL16456842 | 0.63 | DGAT1 (0.40) | HTR2BDGAT1USP30CHRNA7KCNH2 | |
| SCHEMBL6874628 | 0.63 | USP30 (0.59) | HIF1AUSP30MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |