Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB1 | P16118 | 6/20 | 0.49 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.49 |
| ▸ | PFKFB2 | O60825 | 5/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20863893 | 1.00 | PFKFB1 (0.49) | PFKFB1PFKFB3PFKFB2CAPN1MAPT | |
| SCHEMBL24003652 | 0.86 | TSHR (0.47) | PFKFB1PFKFB3PFKFB2MAPTCTSC | |
| SCHEMBL25398492 | 0.86 | TSHR (0.47) | PFKFB1PFKFB3PFKFB2MAPTCTSC | |
| SCHEMBL1088243 | 0.85 | NAMPT (0.44) | PFKFB1PFKFB3PFKFB2CAPN1MAPT | |
| SCHEMBL22295691 | 0.83 | MEN1 (0.49) | PFKFB1PFKFB3PFKFB2CTSCHDAC3 | |
| SCHEMBL20863887 | 0.83 | MEN1 (0.49) | PFKFB1PFKFB3PFKFB2CTSCHDAC3 | |
| SCHEMBL23754360 | 0.81 | SCN3A (0.53) | PFKFB1PFKFB3PFKFB2HDAC3HDAC11 | |
| SCHEMBL23754361 | 0.81 | SCN3A (0.53) | PFKFB1PFKFB3PFKFB2HDAC3HDAC11 | |
| SCHEMBL22295668 | 0.81 | CTSC (0.42) | PFKFB1PFKFB3PFKFB2MAPTCTSC | |
| SCHEMBL27284189 | 0.78 | DPP7 (0.45) | CTSCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3690038-A1 | ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-05 | — | — | EP | disclosed |