Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900003 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2DPP4DPP8ROCK2ROCK1 | |
| SCHEMBL16221905 | 0.85 | DPP4 (0.41) | DPP4DPP8ROCK2ROCK1MMP3 | |
| SCHEMBL9676526 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2DPP4DPP8PREPPOLB | |
| SCHEMBL9675632 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2DPP4DPP8PREPPOLB | |
| SCHEMBL13077436 | 0.85 | DPP4 (0.53) | DPP4DPP8ROCK2ROCK1MMP3 | |
| SCHEMBL7542669 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2DPP4DPP8PREPPOLB | |
| SCHEMBL13077684 | 0.82 | DPP4 (0.48) | DPP4DPP8ROCK2ROCK1POLB | |
| SCHEMBL19432460 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2DPP4DPP8PREPPOLB | |
| SCHEMBL13662567 | 0.82 | ROCK2 (0.46) | DPP4DPP8ROCK2ROCK1POLB | |
| SCHEMBL10272737 | 0.82 | ROCK2 (0.46) | DPP4DPP8ROCK2ROCK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3690049-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |