Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11823665 | 0.78 | KMT2A (0.83) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL5316205 | 0.77 | ELANE (0.70) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL27695051 | 0.77 | KMT2A (0.68) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL13292722 | 0.77 | KMT2A (0.68) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL13135287 | 0.76 | KMT2A (0.61) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL21185911 | 0.76 | HTT (0.61) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL18087028 | 0.75 | KMT2A (0.78) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL13198427 | 0.73 | ELANE (0.59) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL366845 | 0.72 | RAB9A (0.54) | KMT2ATDP1HTTSMN1; SMN2ELANE | |
| SCHEMBL14817286 | 0.72 | KMT2A (0.56) | KMT2ATDP1HTTSMN1; SMN2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738052-B2 | Imidazotriaines and imidazopyrimidines as kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738052-B2 | Imidazotriaines and imidazopyrimidines as kinase inhibitors | MET, RET, ERBB2 | KMT2A 478/4885TDP1 2474/4885HTT 3759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.