Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820137 | 0.85 | HRH4 (0.48) | KDM4EMTNR1AMTNR1BIP6K1MET | |
| SCHEMBL19657531 | 0.82 | PLK1 (0.55) | MTNR1AMTNR1BIP6K1METAXL | |
| SCHEMBL19657956 | 0.82 | ALOX15 (0.55) | KDM4EMTNR1AMTNR1B | |
| SCHEMBL21620547 | 0.81 | KDM4E (0.47) | KDM4EIP6K1METAXLMERTK | |
| SCHEMBL27597844 | 0.79 | LCK (0.44) | KDM4EIP6K1METAXLMERTK | |
| SCHEMBL6202783 | 0.79 | SMYD3 (0.56) | KDM4EIP6K1METAXLMERTK | |
| SCHEMBL26317961 | 0.78 | KDM4E (0.55) | KDM4EMETAXLMERTKMAPK1 | |
| SCHEMBL7230935 | 0.78 | MAP4K4 (0.43) | KDM4EIP6K1METAXLMERTK | |
| SCHEMBL16621441 | 0.77 | TGFBR1 (0.39) | KDM4EMETAXLMERTKKMT2A | |
| SCHEMBL22304443 | 0.77 | KDM4E (0.43) | KDM4EIP6K1METAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247812-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | INTEGRAL BIOSCIENCES PRIVATE LTD (IN) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247812-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | ACVR1, ACVRL1, ALK | KDM4E 998/4885MTNR1A 2207/4885MTNR1B 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.