Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22306588 | 0.94 | SMARCA2 (0.45) | MAPTCSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL22305714 | 0.91 | WNT3A (0.45) | MAPTROCK1PHGDHSMARCA2SMARCA4 | |
| SCHEMBL22305480 | 0.90 | MAPT (0.48) | MAPTCSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL22305951 | 0.89 | MAPT (0.55) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL22290647 | 0.89 | PARP1 (0.47) | MAPTROCK2ROCK1SMARCA2SMARCA4 | |
| SCHEMBL22306345 | 0.89 | ROCK2 (0.47) | MAPTROCK2ROCK1SMARCA2SMARCA4 | |
| SCHEMBL31173242 | 0.89 | PARP1 (0.47) | MAPTROCK2ROCK1SMARCA2SMARCA4 | |
| SCHEMBL22306414 | 0.88 | WNT3A (0.54) | ROCK1SMARCA2SMARCA4KMT2AABL1 | |
| SCHEMBL22305493 | 0.88 | MAPT (0.47) | MAPTCSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL22306303 | 0.88 | MAPT (0.47) | MAPTCSNK2A2CSNK2BCSNK2A1CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |