Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22305368 | 0.89 | MAPT (0.49) | ROCK2ROCK1MAPTNPC1RAB9A | |
| SCHEMBL22306605 | 0.89 | HDAC3 (0.46) | ROCK2ROCK1MAPTNPC1RAB9A | |
| SCHEMBL22305951 | 0.88 | MAPT (0.55) | MAPTNPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL31173242 | 0.87 | PARP1 (0.47) | ROCK2ROCK1MAPTHDAC4SMARCA2 | |
| SCHEMBL22290647 | 0.87 | PARP1 (0.47) | ROCK2ROCK1MAPTHDAC4SMARCA2 | |
| SCHEMBL22305714 | 0.87 | WNT3A (0.45) | ROCK1MAPTSMARCA2SMARCA4ABL1 | |
| SCHEMBL22306596 | 0.86 | ALDH1A1 (0.58) | ROCK1MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL22306588 | 0.86 | SMARCA2 (0.45) | MAPTHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL22305355 | 0.86 | SMARCA2 (0.46) | MAPTNPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL22306586 | 0.85 | SMARCA2 (0.43) | ROCK1HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |