Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22306478 | 0.84 | POLB (0.34) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL22290358 | 0.81 | PHGDH (0.48) | SMN1; SMN2KDM1AHDAC1CSNK1D | |
| SCHEMBL31173227 | 0.81 | PHGDH (0.48) | SMN1; SMN2KDM1AHDAC1CSNK1D | |
| SCHEMBL22306735 | 0.80 | USP2 (0.33) | SMN1; SMN2L3MBTL1KDM1AHDAC1CSNK1D | |
| SCHEMBL22305518 | 0.80 | ADORA2A (0.32) | — | |
| SCHEMBL22305520 | 0.80 | ADORA2A (0.32) | — | |
| SCHEMBL22306196 | 0.79 | CCR2 (0.34) | SMN1; SMN2 | |
| SCHEMBL22306616 | 0.79 | L3MBTL1 (0.32) | SMN1; SMN2L3MBTL1KDM1AHDAC1NAMPT | |
| SCHEMBL22306597 | 0.76 | — | — | |
| SCHEMBL22305377 | 0.76 | HTR1A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |