Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233135 | 0.85 | ESR1 (0.48) | APPESR1 | |
| SCHEMBL13582316 | 0.84 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL13582313 | 0.84 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL2230608 | 0.80 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL3134922 | 0.78 | HSPB1 (0.53) | MAPTALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL3134912 | 0.78 | HSPB1 (0.53) | MAPTALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL2232561 | 0.78 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2HSPB1KDM4E | |
| SCHEMBL28368058 | 0.75 | APP (0.52) | MAPTALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL27463292 | 0.75 | APP (0.52) | MAPTALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL2230605 | 0.74 | PPARG (0.43) | MAPTALDH1A1SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093524-A1 | DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |