Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.43 |
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233144 | 0.85 | ALOX5 (0.47) | ALOX5PTGESPPARGPSEN1 | |
| SCHEMBL2230602 | 0.80 | MAPT (0.44) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2230605 | 0.80 | PPARG (0.43) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13582316 | 0.78 | MAPT (0.50) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13582313 | 0.78 | MAPT (0.50) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2232569 | 0.77 | MAPT (0.54) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6175971 | 0.72 | HSPB1 (0.55) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6208366 | 0.72 | HSPB1 (0.60) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22529936 | 0.71 | HSPB1 (0.59) | MAPTHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29351818 | 0.71 | HSPB1 (0.59) | MAPTHTTSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093524-A1 | DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |