Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11431170 | 0.85 | PLA2G4B (0.68) | ALDH1A1PLA2G4BPTGS2MAPTPOLB | |
| SCHEMBL22307858 | 0.81 | ALDH1A1 (0.58) | ALDH1A1PTGS2MAPTPOLBKMT2A | |
| SCHEMBL29158559 | 0.80 | ALDH1A1 (0.60) | ALDH1A1PLA2G4BPTGS2MAPTPOLB | |
| SCHEMBL6602827 | 0.79 | ALDH1A1 (0.62) | ALDH1A1PTGS2MAPTPOLBKMT2A | |
| SCHEMBL8770176 | 0.79 | KMT2A (0.62) | ALDH1A1PTGS2MAPTPOLBKMT2A | |
| SCHEMBL19938038 | 0.79 | ALDH1A1 (0.62) | ALDH1A1PLA2G4BPTGS2MAPTPOLB | |
| SCHEMBL14453837 | 0.78 | BCL9 (0.65) | ALDH1A1PTGS2MAPTKMT2AGAA | |
| SCHEMBL8021419 | 0.77 | ALOX15 (0.57) | PLA2G4BMAPTPOLBKMT2AMEN1 | |
| SCHEMBL3045885 | 0.77 | MAPT (0.68) | ALDH1A1PTGS2MAPTPOLBKMT2A | |
| SCHEMBL10643488 | 0.77 | ALDH1A1 (0.64) | ALDH1A1PTGS2MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | ALDH1A1 3564/4885PLA2G4B 832/4885PTGS2 2325/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | ALDH1A1 3111/4885PLA2G4B 850/4885PTGS2 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.