Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915190 | 0.83 | HTR6 (0.45) | AKR1B1PKMALDH1A1HSD17B10SLC9A1 | |
| SCHEMBL14434942 | 0.78 | GAA (0.46) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22308264 | 0.76 | AKR1B1 (0.44) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307533 | 0.74 | NLRP3 (0.48) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307512 | 0.74 | NLRP3 (0.48) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307513 | 0.72 | NLRP3 (0.47) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307523 | 0.72 | NLRP3 (0.47) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307525 | 0.72 | NLRP3 (0.47) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307931 | 0.72 | NLRP3 (0.47) | GAAAKR1B1NR1I2HSP90AA1NLRP3 | |
| SCHEMBL22307440 | 0.71 | NLRP3 (0.53) | GAAAKR1B1NR1I2HSP90AA1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | GAA 3688/4885AKR1B1 2660/4885NR1I2 2549/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | GAA 3226/4885AKR1B1 1943/4885NR1I2 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.