Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308475 | 0.83 | LMNA (0.41) | LMNAPRSS1PRSS2PRSS3SLC2A1 | |
| SCHEMBL22307824 | 0.83 | LMNA (0.41) | LMNAPRSS1PRSS2PRSS3SLC2A1 | |
| SCHEMBL29058174 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3CSNK1E | |
| SCHEMBL21770640 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3CSNK1E | |
| SCHEMBL19732279 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3CSNK1E | |
| SCHEMBL19963496 | 0.77 | LMNA (0.38) | LMNAPRSS1PRSS2PRSS3SLC2A1 | |
| SCHEMBL23844725 | 0.76 | KCNH2 (0.42) | LMNAPRSS1PRSS2PRSS3CSNK1E | |
| SCHEMBL18647910 | 0.76 | KCNH2 (0.42) | LMNAPRSS1PRSS2PRSS3CSNK1E | |
| SCHEMBL9819021 | 0.73 | NAAA (0.50) | LMNAKDM4EUSP2ALOX15ALOX12 | |
| SCHEMBL7524061 | 0.73 | NAAA (0.50) | LMNAKDM4EUSP2ALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | LMNA 4191/4885PRSS1 1598/4885PRSS2 2500/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | LMNA 4093/4885PRSS1 2288/4885PRSS2 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.