Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | ADA | P00813 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308475 | 1.00 | LMNA (0.41) | LMNASLC2A1PRSS1PRSS2PRSS3 | |
| SCHEMBL22308297 | 0.83 | LMNA (0.42) | LMNASLC2A1PRSS1PRSS2PRSS3 | |
| SCHEMBL20901211 | 0.76 | FAAH (0.39) | LMNASLC2A1PRSS1PRSS2PRSS3 | |
| SCHEMBL19963496 | 0.75 | LMNA (0.38) | LMNASLC2A1PRSS1PRSS2PRSS3 | |
| SCHEMBL20499801 | 0.74 | KCNH2 (0.42) | LMNA | |
| SCHEMBL28091635 | 0.74 | KCNH2 (0.42) | LMNA | |
| SCHEMBL28254738 | 0.74 | KCNH2 (0.42) | LMNA | |
| SCHEMBL20747030 | 0.74 | KCNH2 (0.42) | LMNA | |
| SCHEMBL27794520 | 0.74 | KCNH2 (0.42) | LMNA | |
| SCHEMBL22307857 | 0.73 | NR1I2 (0.36) | LMNASLC2A1ADAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | LMNA 4191/4885SLC2A1 3742/4885PRSS1 1598/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | LMNA 4093/4885SLC2A1 3566/4885PRSS1 2288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.