Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22309752 | 0.87 | NPM1 (0.37) | MAPTNPC1ALDH1A1MAPK1RAB9A | |
| SCHEMBL18548700 | 0.79 | MCL1 (0.39) | ALDH1A1ALOX15TSHRSMN1; SMN2MCL1 | |
| SCHEMBL29660262 | 0.79 | MCL1 (0.39) | ALDH1A1ALOX15TSHRSMN1; SMN2MCL1 | |
| SCHEMBL22309750 | 0.77 | TP53 (0.36) | MAPTNPC1ALDH1A1TP53ALOX15 | |
| SCHEMBL2163722 | 0.76 | PTPN1 (0.44) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31031257 | 0.73 | ALDH1A1 (0.41) | MAPTNPC1ALDH1A1TP53ALOX15 | |
| SCHEMBL29660237 | 0.72 | ALDH1A1 (0.49) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL18548712 | 0.72 | ALDH1A1 (0.49) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL22310380 | 0.69 | NPM1 (0.35) | MAPTALOX15BACE1CYP1A2CYP2C19 | |
| SCHEMBL19714775 | 0.68 | ALDH1A1 (0.45) | MAPTNPC1ALDH1A1TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3919492-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | Medshine Discovery Inc. (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020156453-A1 | PYRIMIDINYL GROUP-CONTAINING TRICYCLIC COMPOUND SERVING AS C-MET INHIBITOR | 南京明德新药研发有限公司 | 2020-08-06 | — | — | WO | disclosed |