Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18548712 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP1A2ADORA2BELANE | |
| SCHEMBL18548610 | 0.91 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2CYP1A2ADORA2BELANE | |
| SCHEMBL27365441 | 0.86 | DPP4 (0.48) | ALDH1A1CYP1A2ADORA2BKDM4EHPGD | |
| SCHEMBL29660209 | 0.85 | KDM4E (0.46) | ALDH1A1SMN1; SMN2CYP1A2ELANELMNA | |
| SCHEMBL18548622 | 0.85 | KDM4E (0.46) | ALDH1A1SMN1; SMN2CYP1A2ELANELMNA | |
| SCHEMBL29660200 | 0.83 | CYP1A2 (0.51) | ALDH1A1SMN1; SMN2CYP1A2MAPTNPC1 | |
| SCHEMBL18548710 | 0.83 | CYP1A2 (0.51) | ALDH1A1SMN1; SMN2CYP1A2MAPTNPC1 | |
| SCHEMBL29660262 | 0.81 | MCL1 (0.39) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18548700 | 0.81 | MCL1 (0.39) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL18548688 | 0.78 | KDM4E (0.49) | ALDH1A1SMN1; SMN2CYP1A2ELANELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | ALDH1A1 3976/4885SMN1; SMN2 106/4885CYP1A2 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.