SCHEMBL2231333

SCHEMBL2231333

CC1=C(c2ccc(N3C(=O)C=CC3=O)cc2)C(=O)NC1=O

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 14/20 0.52
FAAH O00519 5/20 0.50
HSP90AA1 P07900 5/20 0.43
TDP1 Q9NUW8 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
PKM P14618 1/20 0.43
MAPK1 P28482 1/20 0.43
ALDH1A1 P00352 2/20 0.40
CACNA1B Q00975 2/20 0.40
APBA1 Q02410 2/20 0.40
HPGD P15428 1/20 0.40
HTT P42858 1/20 0.40
DDAH1 O94760 1/20 0.40
CCR6 P51684 2/20 0.39
BCHE P06276 1/20 0.39
LMNA P02545 1/20 0.39
APOBEC3G Q9HC16 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28818338 0.88 MGLL (0.60) MGLLFAAHHSP90AA1TDP1NPSR1
SCHEMBL7193397 0.82 PTGS2 (0.48)
SCHEMBL2230096 0.78 MGLL (0.42) MGLLFAAHHSP90AA1NPSR1PKM
SCHEMBL2228525 0.78 MGLL (0.44) MGLLFAAHHSP90AA1TDP1NPSR1
SCHEMBL1164429 0.76 PTGS2 (0.58) ALDH1A1HPGDLMNA
SCHEMBL28098670 0.76 MGLL (0.61) MGLLFAAH
SCHEMBL19511560 0.73 MGLL (0.83) MGLLFAAHHSP90AA1TDP1NPSR1
SCHEMBL21630074 0.73 MGLL (0.83) MGLLFAAHHSP90AA1TDP1NPSR1
SCHEMBL1321309 0.73 MGLL (0.83) MGLLFAAHHSP90AA1TDP1NPSR1
SCHEMBL3791544 0.73 PTGS2 (0.46) TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11230636-B2 Rubber composition having improved properties in the raw state and in the cooked state COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2022-01-25 US claimed
EP-3582977-B1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE MICHELIN & CIE (FR) 2021-03-31 EP claimed
US-20200056017-A1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2020-02-20 US claimed
WO-2018150136-A1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-08-23 WO claimed
JP-4717814-B2 2011-07-06 JP claimed
US-7442733-B2 Rubber composition comprising a citraconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2008-10-28 US claimed
US-20060247342-A1 Rubber composition comprising a citraconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. 2006-11-02 US claimed
EP-1664180-A1 RUBBER COMPOSITION COMPRISING A CITRACONIMIDO-MALEIMIDE Société de Technologie Michelin (FR) 2006-06-07 EP claimed
WO-2005026250-A1 RUBBER COMPOSITION COMPRISING A CITRACONIMIDO-MALEIMIDE SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2005-03-24 WO claimed
US-11230636-B2 Rubber composition having improved properties in the raw state and in the cooked state COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2022-01-25 US disclosed
EP-3582977-B1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE MICHELIN & CIE (FR) 2021-03-31 EP disclosed
US-20200056017-A1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2020-02-20 US disclosed
WO-2018150136-A1 RUBBER COMPOSITION HAVING IMPROVED PROPERTIES IN THE RAW STATE AND IN THE COOKED STATE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-08-23 WO disclosed
US-7442733-B2 Rubber composition comprising a citraconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2008-10-28 US disclosed
US-20060247342-A1 Rubber composition comprising a citraconimidomaleimide MICHELIN RECHERCHE ET TECHNIQUE S.A. 2006-11-02 US disclosed
EP-1664180-A1 RUBBER COMPOSITION COMPRISING A CITRACONIMIDO-MALEIMIDE Société de Technologie Michelin (FR) 2006-06-07 EP disclosed
WO-2005026250-A1 RUBBER COMPOSITION COMPRISING A CITRACONIMIDO-MALEIMIDE SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2005-03-24 WO disclosed