Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 11/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 10/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 10/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22648503 | 1.00 | GNAO1 (0.41) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL18852718 | 0.93 | GNAI3 (0.36) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL22648461 | 0.93 | GNAO1 (0.43) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL25044308 | 0.93 | GNAO1 (0.43) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL21120419 | 0.91 | GNAO1 (0.42) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL24123133 | 0.91 | GNAO1 (0.42) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL18879327 | 0.86 | GNAO1 (0.41) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL21653951 | 0.85 | GNAO1 (0.38) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL22031162 | 0.85 | GNAI3 (0.33) | GNAO1GNAI3GNAI1 | |
| SCHEMBL19230301 | 0.83 | HTT (0.39) | GNAO1GNAI3GNAI1PAOXHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208405-B2 | Pyrrole derivatives as PLK1 inhibitors | SENTINEL ONCOLOGY LIMITED (GB) | 2021-12-28 | — | — | US | disclosed |
| US-20200247796-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247796-A1 | PYRROLE DERIVATIVES AS PLK1 INHIBITORS | PLK1, CDK1, AURKC | GNAO1 3352/4885GNAI3 3927/4885GNAI1 3633/4885 |
| US-11208405-B2 | Pyrrole derivatives as PLK1 inhibitors | PLK1, CDK1, AURKC | GNAO1 3352/4885GNAI3 3927/4885GNAI1 3633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.