Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 11/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 10/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25044308 | 1.00 | GNAO1 (0.43) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL21120419 | 0.98 | GNAO1 (0.42) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL24123133 | 0.98 | GNAO1 (0.42) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL22648503 | 0.93 | GNAO1 (0.41) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL22318014 | 0.93 | GNAO1 (0.41) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL21653951 | 0.92 | GNAO1 (0.38) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL18852718 | 0.85 | GNAI3 (0.36) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL24335467 | 0.85 | GNAO1 (0.40) | GNAO1GNAI3GNAI1NPC1TP53 | |
| SCHEMBL25005825 | 0.85 | LTA4H (0.38) | GNAO1GNAI3GNAI1ALDH1A1L3MBTL1 | |
| SCHEMBL22624141 | 0.85 | GNAO1 (0.35) | GNAO1GNAI3GNAI1THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200354367-A1 | COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | XBP1, RNASE1, ERN1 | GNAO1 2878/4885GNAI3 2035/4885GNAI1 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.