Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | MELK | Q14680 | 3/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28790211 | 0.86 | CYP8B1 (0.38) | CYP8B1MAPTFFAR4MELKMEN1 | |
| SCHEMBL12367226 | 0.78 | ADRB2 (0.42) | CYP8B1MAPTADRB2MEN1KMT2A | |
| SCHEMBL2205071 | 0.77 | BTK (0.52) | MEN1KMT2ABTK | |
| SCHEMBL28790212 | 0.77 | MEN1 (0.37) | CYP8B1MAPTMELKMEN1KMT2A | |
| SCHEMBL20445960 | 0.70 | CHRM5 (0.38) | MEN1KMT2A | |
| SCHEMBL22829714 | 0.70 | ALDH1A1 (0.42) | CYP8B1MAPTMEN1KMT2A | |
| SCHEMBL1318206 | 0.69 | LMNA (0.48) | MAPTKMT2A | |
| SCHEMBL1322166 | 0.69 | LMNA (0.48) | MAPTKMT2A | |
| SCHEMBL22499812 | 0.68 | ACACB (0.40) | — | |
| SCHEMBL22499813 | 0.68 | ACACB (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342190-A1 | BICYCLIC KINASE INHIBITORS | Novartis AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |