Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 5/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20742698 | 0.86 | MAPT (0.43) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL20262700 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL22320514 | 0.81 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL18342662 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL22320612 | 0.77 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1LMNAKDRTEK | |
| SCHEMBL22320697 | 0.76 | NOTUM (0.38) | SMN1; SMN2LMNAKITKDRTEK | |
| SCHEMBL2369189 | 0.76 | KDR (0.55) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL16815522 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL1604258 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1LMNAKITKDR | |
| SCHEMBL19149232 | 0.73 | LMNA (0.38) | SMN1; SMN2ALDH1A1LMNAKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255451-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255451-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | MCL1, BCL2A1, BCL2L10 | SMN1; SMN2 609/4885ALDH1A1 647/4885LMNA 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.